Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model

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dc.creatorSilvia Iovine Kobata
dc.creatorLuiz Eduardo Moreira Teixeira
dc.creatorSimone Odília Antunes Fernandes
dc.creatorAndré Augusto Gomes Faraco
dc.creatorPaula Vieira Teixeira Vidigal
dc.creatorIvana Duval de Araújo
dc.date.accessioned2022-04-08T23:14:38Z
dc.date.accessioned2025-09-08T23:53:29Z
dc.date.available2022-04-08T23:14:38Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1590/s0102-865020200080000003
dc.identifier.issn1678-2674
dc.identifier.urihttps://hdl.handle.net/1843/40943
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectInfecção óssea
dc.subjectQuitosana
dc.subjectCiprofloxacina
dc.subject.otherOsteitis
dc.subject.otherChitosan
dc.subject.otherCiprofloxacin
dc.subject.otherFractures
dc.subject.otherOpen
dc.subject.otherRats
dc.titlePrevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issue8
local.citation.spage1
local.citation.volume35
local.description.resumoPurpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables. Results Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05). Conclusion Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/acb/a/sKyMmtWm8F4dSvSpcg753Pd/?lang=en

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