Copper complexes and carbon nanotube–copper ferrite-catalyzed benzenoid A-ring selenation of quinones: an efficient method for the synthesis of trypanocidal agents
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
We report a new method for A-ring selenation of naphthoquinones and anthraquinones and discuss the relevant trypanocidal activity of the synthesized compounds. We have demonstrated three efficient strategies for the preparation of the target selenium derivatives, i.e. (a) copper(I) thiophene-2-carboxylate and in situ generated Santi's reagent were used to prepare selenium-substituted benzenoid quinones, (b) copper complexes and (c) carbon nanotube-supported copper ferrite as catalysts in the presence of AgSeR-salts were also used for the synthesis of selenium-containing quinoidal derivatives. These new methods provide efficient and practical strategies for the preparation of selenium-based quinones. In addition, we have discovered nine compounds with potent trypanocidal activity. The derivatives 2a–2e showed potent trypanocidal activity with IC50 values in the range of 13.3 to 37.0 μM.
Abstract
Assunto
Síntese orgânica, Compostos orgânicos, Selênio, Antraquinonas, Cristalografia de raio X, Nanotubos de carbono, Agentes antineoplasicos, Complexos metálicos
Palavras-chave
Selenium, Naphthoquinones, Anthraquinones, Selenium-based quinones, Trypanocidal activity, Copper complexes, Carbon nanotube
Citação
Departamento
Curso
Endereço externo
https://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj02026h