Copper complexes and carbon nanotube–copper ferrite-catalyzed benzenoid A-ring selenation of quinones: an efficient method for the synthesis of trypanocidal agents

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dc.creatorGuilherme Augusto de Melo Jardim
dc.creatorIcaro Antônio Oliveira Bozzi
dc.creatorWillian Xerxes Coelho Oliveira
dc.creatorCamila Mesquita Rodrigues
dc.creatorRubem Figueiredo Sadok Menna Barreto
dc.creatorRamar Arun Kumar
dc.creatorEdmond Gravel
dc.creatorEric Doris
dc.creatorAntonio Luiz Braga
dc.creatorEufrânio Nunes da Silva Júnior
dc.date.accessioned2023-02-14T18:02:54Z
dc.date.accessioned2025-09-09T01:04:48Z
dc.date.available2023-02-14T18:02:54Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.identifier.doihttps://doi.org/10.1039/C9NJ02026H
dc.identifier.issn1369-9261
dc.identifier.urihttps://hdl.handle.net/1843/50037
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectSíntese orgânica
dc.subjectCompostos orgânicos
dc.subjectSelênio
dc.subjectAntraquinonas
dc.subjectCristalografia de raio X
dc.subjectNanotubos de carbono
dc.subjectAgentes antineoplasicos
dc.subjectComplexos metálicos
dc.subject.otherSelenium
dc.subject.otherNaphthoquinones
dc.subject.otherAnthraquinones
dc.subject.otherSelenium-based quinones
dc.subject.otherTrypanocidal activity
dc.subject.otherCopper complexes
dc.subject.otherCarbon nanotube
dc.titleCopper complexes and carbon nanotube–copper ferrite-catalyzed benzenoid A-ring selenation of quinones: an efficient method for the synthesis of trypanocidal agents
dc.typeArtigo de periódico
local.citation.epage13763
local.citation.issue35
local.citation.spage13751
local.citation.volume43
local.description.resumoWe report a new method for A-ring selenation of naphthoquinones and anthraquinones and discuss the relevant trypanocidal activity of the synthesized compounds. We have demonstrated three efficient strategies for the preparation of the target selenium derivatives, i.e. (a) copper(I) thiophene-2-carboxylate and in situ generated Santi's reagent were used to prepare selenium-substituted benzenoid quinones, (b) copper complexes and (c) carbon nanotube-supported copper ferrite as catalysts in the presence of AgSeR-salts were also used for the synthesis of selenium-containing quinoidal derivatives. These new methods provide efficient and practical strategies for the preparation of selenium-based quinones. In addition, we have discovered nine compounds with potent trypanocidal activity. The derivatives 2a–2e showed potent trypanocidal activity with IC50 values in the range of 13.3 to 37.0 μM.
local.identifier.orcidhttps://orcid.org/0000-0002-9882-3085
local.identifier.orcidhttps://orcid.org/0000-0002-0696-0833
local.identifier.orcidhttps://orcid.org/0000-0003-0722-5352
local.identifier.orcidhttps://orcid.org/0000-0002-1352-0641
local.identifier.orcidhttps://orcid.org/0000-0002-5209-8463
local.identifier.orcidhttps://orcid.org/0000-0001-6077-1016
local.identifier.orcidhttps://orcid.org/0000-0003-1318-602X
local.identifier.orcidhttps://orcid.org/0000-0001-9903-6764
local.identifier.orcidhttps://orcid.org/0000-0003-1281-5453
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj02026h

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