Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? a systematic review
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
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Background
The most accurate data help to minimize possible mistakes on a patient´s evaluation, as more robust findings are necessary to establish a correct diagnosis, prognosis and, consequently, better treatment.
Purpose
Could biomarker levels in the saliva help to distinguish between healthy implants and implants with peri-implant disease?
Materials and methods
An electronic database search of Pubmed/MEDLINE, Web of Science, the Cochrane Library, OVID and Scielo was performed. The articles and abstracts identified were considered relevant if they compared cytokine levels in saliva from patients with healthy implants to those in saliva from patients with untreated peri-implantitis.
Results
Lower salivary levels of interleukin 1β were found in healthy implants than in inflamed implants. A significantly positive correlation was found between the salivary levels of IL-6 and peri-implant inflammatory conditions. The salivary concentrations of total antioxidants, urate and ascorbate were higher in healthy implants than in inflamed implants. The data extracted from the 6 studies evaluated in this review revealed heterogeneity in relation to the clinical parameters assessed, implant restoration, bone loss and peri-implant disease definitions.
Conclusions
There was no clear, developed basis for using any specific biomarker in a clinical setting to distinguish between healthy implants and those with peri implant disease.
Abstract
Assunto
Chemokines, Cytokines, Dental implants, Peri-implantitis, Mucositis, Saliva, Biomarkers, Interleukin-1beta, Interleukin-6, Antioxidants
Palavras-chave
biomarkers, salivary levels, Peri-implant Disease busca dia 22/04/2024 assunto Chemokines periódico: Archives of oral biology fao clínica Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? a systematic review, Keywords ChemokinesCytokines Dental implants Peri-implantitis Mucositissaliva
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Endereço externo
https://www.sciencedirect.com/science/article/pii/S0003996918305922