Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? a systematic review

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dc.creatorAlex Martins Gomes
dc.creatorDhelfeson Willya Douglas-de Oliveira
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2024-04-29T18:29:25Z
dc.date.accessioned2025-09-09T00:30:09Z
dc.date.available2024-04-29T18:29:25Z
dc.date.issued2018-12
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2018.09.008
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/67849
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectChemokines
dc.subjectCytokines
dc.subjectDental implants
dc.subjectPeri-implantitis
dc.subjectMucositis
dc.subjectSaliva
dc.subjectBiomarkers
dc.subjectInterleukin-1beta
dc.subjectInterleukin-6
dc.subjectAntioxidants
dc.subject.otherbiomarkers
dc.subject.othersalivary levels
dc.subject.otherPeri-implant Disease busca dia 22/04/2024 assunto Chemokines periódico: Archives of oral biology fao clínica Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? a systematic review
dc.subject.otherKeywords ChemokinesCytokines Dental implants Peri-implantitis Mucositissaliva
dc.titleCould the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? a systematic review
dc.typeArtigo de periódico
local.citation.epage222
local.citation.spage216
local.citation.volume96
local.description.resumoBackground The most accurate data help to minimize possible mistakes on a patient´s evaluation, as more robust findings are necessary to establish a correct diagnosis, prognosis and, consequently, better treatment. Purpose Could biomarker levels in the saliva help to distinguish between healthy implants and implants with peri-implant disease? Materials and methods An electronic database search of Pubmed/MEDLINE, Web of Science, the Cochrane Library, OVID and Scielo was performed. The articles and abstracts identified were considered relevant if they compared cytokine levels in saliva from patients with healthy implants to those in saliva from patients with untreated peri-implantitis. Results Lower salivary levels of interleukin 1β were found in healthy implants than in inflamed implants. A significantly positive correlation was found between the salivary levels of IL-6 and peri-implant inflammatory conditions. The salivary concentrations of total antioxidants, urate and ascorbate were higher in healthy implants than in inflamed implants. The data extracted from the 6 studies evaluated in this review revealed heterogeneity in relation to the clinical parameters assessed, implant restoration, bone loss and peri-implant disease definitions. Conclusions There was no clear, developed basis for using any specific biomarker in a clinical setting to distinguish between healthy implants and those with peri implant disease.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996918305922

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