Serological survey for igg antibodies against sars-cov-2 through newborn screening
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Universidade Federal de Minas Gerais
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Artigo de periódico
Título alternativo
Inquérito sorológico para anticorpos IgG contra SARS-CoV-2 de recém-nascidos e suas mães
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Membros da banca
Resumo
This serological survey, conducted in five Brazilian municipalities, evaluated the use of dried blood spots (DBS), obtained from newborns and their mothers, to detect SARS-CoV-2 IgG antibodies. DBS were obtained from 4,803 neonates aged up to seven days and their mothers, both asymptomatic, at public health care clinics during newborn screening. DBS were processed by ELISA
to detect IgG antibodies against SARS-CoV-2 nucleocapsid antigen. Mothers of seropositive neonates were interviewed about sociodemographic char acteristics and clinical and laboratory antecedents. Non-satisfactory samples, dyads with incomplete data, and vaccinated mothers were excluded. Of the 1,917 DBS dyads samples analyzed, 14.7% of neonates showed IgG antibodies
against SARS-CoV-2. Among seropositive neonates, 73.2% of their mothers were also seropositive. More than half of the mothers with seropositive neonates denied clinical or laboratory suspicion of COVID-19 during pregnancy. Suspicion occurred in the third trimester for 24.6% of the mothers. This study tested an innovative strategy to improve the understanding of COVID-19 antibody dynamics during pregnancy and suggests the feasibility of a universal serological survey in puerperal women and neonates.
Abstract
Assunto
SARS-CoV-2, Newborn, Pregnancy, Neonatal Screening
Palavras-chave
SARS-CoV-2, Newborn, Pregnancy, Neonatal Screening
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https://doi.org/10.1590/0102-311XEN021022