Serological survey for igg antibodies against sars-cov-2 through newborn screening

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dc.creatorVívian Mara Gonçalves de Oliveira Azevedo
dc.creatorClaudia Regina Lindgren Alves
dc.creatorGabriela Soutto Mayor Assumpção Pinheiro
dc.creatorAline Almeida Bentes
dc.creatorGabriela Cintra Januário
dc.creatorJosé Nélio Januário
dc.creatorMila Lemos Cintra
dc.creatorAna Beatriz Araújo de Souza
dc.creatorLaura Gregório Pires
dc.creatorStela Maris Aguiar Lemos
dc.date.accessioned2023-12-06T23:42:45Z
dc.date.accessioned2025-09-08T22:55:53Z
dc.date.available2023-12-06T23:42:45Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doi10.1590/0102-311XEN021022
dc.identifier.issn16784464
dc.identifier.urihttps://hdl.handle.net/1843/61828
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCadernos de Saúde Pública
dc.rightsAcesso Aberto
dc.subjectSARS-CoV-2
dc.subjectNewborn
dc.subjectPregnancy
dc.subjectNeonatal Screening
dc.subject.otherSARS-CoV-2
dc.subject.otherNewborn
dc.subject.otherPregnancy
dc.subject.otherNeonatal Screening
dc.titleSerological survey for igg antibodies against sars-cov-2 through newborn screening
dc.title.alternativeInquérito sorológico para anticorpos IgG contra SARS-CoV-2 de recém-nascidos e suas mães
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue8
local.citation.spage1
local.citation.volume38
local.description.resumoThis serological survey, conducted in five Brazilian municipalities, evaluated the use of dried blood spots (DBS), obtained from newborns and their mothers, to detect SARS-CoV-2 IgG antibodies. DBS were obtained from 4,803 neonates aged up to seven days and their mothers, both asymptomatic, at public health care clinics during newborn screening. DBS were processed by ELISA to detect IgG antibodies against SARS-CoV-2 nucleocapsid antigen. Mothers of seropositive neonates were interviewed about sociodemographic char acteristics and clinical and laboratory antecedents. Non-satisfactory samples, dyads with incomplete data, and vaccinated mothers were excluded. Of the 1,917 DBS dyads samples analyzed, 14.7% of neonates showed IgG antibodies against SARS-CoV-2. Among seropositive neonates, 73.2% of their mothers were also seropositive. More than half of the mothers with seropositive neonates denied clinical or laboratory suspicion of COVID-19 during pregnancy. Suspicion occurred in the third trimester for 24.6% of the mothers. This study tested an innovative strategy to improve the understanding of COVID-19 antibody dynamics during pregnancy and suggests the feasibility of a universal serological survey in puerperal women and neonates.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE FONOAUDIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/0102-311XEN021022

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