Prognosis and survival immunohistochemical markers of patients with oral squamous cell carcinoma: a systematic review

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dc.creatorGuilherme Trafani Sanches
dc.creatorLucyene Miguita Luiz
dc.creatorIsabela Porto de Toledo
dc.creatorEliete Neves Silva Guerra
dc.creatorFabio Daumas Nunes
dc.date.accessioned2025-09-02T19:42:59Z
dc.date.accessioned2025-09-09T00:58:13Z
dc.date.available2025-09-02T19:42:59Z
dc.date.issued2020-09
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2020.04.756
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/84790
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectProteins
dc.subjectBiomarkers
dc.subjectPrognosis
dc.subjectSurvival rate
dc.subjectImmunohistochemistry
dc.subjectSquamous cell carcinoma of head and neck
dc.titlePrognosis and survival immunohistochemical markers of patients with oral squamous cell carcinoma: a systematic review
dc.typeArtigo de periódico
local.citation.epagee276
local.citation.issue3
local.citation.spagee276
local.citation.volume130
local.description.resumoOral squamous cell carcinoma is the most common malignant neoplasm of the oral cavity and is characterized by low survival rate and adverse prognosis. Objective: This study aimed to summarize accurately the scientific information about immunohistochemical markers related to prognosis and survival in patients with oral squamous cell carcinoma, due to the lack of one specific marker considered to be reliable to predict the behavior of this disease. Study Design: Articles written in English and published between 2007-2017 were chosen from PubMed, Scopus, Web of Science, LILACS, and LIVIVO databases. Results: A total of 2972 articles were found. After inclusion and exclusion criteria, 362 articles were followed for qualitative analysis and risk of bias definition of each article. One hundred twenty-eight articles with a high risk of bias were found; 90 had a moderate risk of bias and 144 had a low risk of bias. These 144 articles described 148 immunohistochemical markers for prognosis and survival. Among these markers, Ecadherin, Ki-67, b-catenin and CA9 were the most studied markers in at least 3 articles. Conclusion: These results suggest that these 4 proteins should be considered for future follow-up studies evaluating biological markers of prognosis and survival in patients with oral squamous cell carcinoma.
local.identifier.orcidhttps://orcid.org/0000-0002-2604-5210
local.identifier.orcidhttps://orcid.org/0000-0003-2958-3265
local.identifier.orcidhttps://orcid.org/0000-0002-7622-1550
local.identifier.orcidhttps://orcid.org/0000-0002-7785-6785
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S221244032030910X

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