Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia

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Artigo de periódico

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Resumo

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12–19, 20–29, 30–34 and 35–40 weeks of gestation.Results: D-Di was lower at 12–19 weeks and higher at 30–34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn’t differ between groups. Conclusion: D-Di was able to discriminate these groups of women at 12–19 and 30–34 weeks of gestation.

Abstract

Assunto

Pré-Eclâmpsia, Estudos Longitudinais, Trombofilia

Palavras-chave

Preemclampisia, D-dimer, Longitudinal Study, Pai 1, Hypercoagulability

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Endereço externo

https://www.tandfonline.com/doi/abs/10.1080/10641955.2019.1577435?journalCode=ihip20

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