Structural elucidation and free radical scavenging activity of a new-orsellinic acid derivative isolated from the lichen Cladonia rappii
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Rappiidic acid, a new o-orsellinic acid derivative, was isolated from the lichen Cladonia rappii. Its capability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was investigated and compared with resveratrol and (+)-usnic acid. Usnic acid at 100 μM was the most efficient ROS scavenger, exhibiting activity 3-fold higher than that of resveratrol. At the same concentration, rappidic acid scavenged 23.1% of ROS formed, demonstratingthat this compound is twice as active as resveratrol. Both compounds were shown to be poor RNS scavengers.
Abstract
Assunto
Produtos naturais, Superóxido, Cladoniacea, Espectroscopia de ressonância nuclear, Cromatografia liquida, Ácidos
Palavras-chave
Rappiidic acid, Orsellinic acid, Natural products, Cladonia rappii, Free radical scavenging, Superoxide anion
Citação
Curso
Endereço externo
https://journals.sagepub.com/doi/abs/10.1177/1934578X1601100932