Structural elucidation and free radical scavenging activity of a new-orsellinic acid derivative isolated from the lichen Cladonia rappii

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dc.creatorTiago Coelho de Assis Lage
dc.creatorLívia Pereira Horta
dc.creatorRicardo Marques Montanari
dc.creatorJefferson Guilherme da Silva
dc.creatorAngelo de Fatima
dc.creatorSergio Antonio Fernandes
dc.creatorLuzia Valentina Modolo
dc.date.accessioned2024-01-19T19:22:23Z
dc.date.accessioned2025-09-08T23:20:35Z
dc.date.available2024-01-19T19:22:23Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1177/1934578X1601100932
dc.identifier.issn1555-9475
dc.identifier.urihttps://hdl.handle.net/1843/63164
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNatural Product Communications
dc.rightsAcesso Aberto
dc.subjectProdutos naturais
dc.subjectSuperóxido
dc.subjectCladoniacea
dc.subjectEspectroscopia de ressonância nuclear
dc.subjectCromatografia liquida
dc.subjectÁcidos
dc.subject.otherRappiidic acid
dc.subject.otherOrsellinic acid
dc.subject.otherNatural products
dc.subject.otherCladonia rappii
dc.subject.otherFree radical scavenging
dc.subject.otherSuperoxide anion
dc.titleStructural elucidation and free radical scavenging activity of a new-orsellinic acid derivative isolated from the lichen Cladonia rappii
dc.typeArtigo de periódico
local.citation.epage1312
local.citation.issue9
local.citation.spage1311
local.citation.volume11
local.description.resumoRappiidic acid, a new o-orsellinic acid derivative, was isolated from the lichen Cladonia rappii. Its capability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was investigated and compared with resveratrol and (+)-usnic acid. Usnic acid at 100 μM was the most efficient ROS scavenger, exhibiting activity 3-fold higher than that of resveratrol. At the same concentration, rappidic acid scavenged 23.1% of ROS formed, demonstratingthat this compound is twice as active as resveratrol. Both compounds were shown to be poor RNS scavengers.
local.identifier.orcidhttps://orcid.org/0000-0003-0007-5216
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0002-8033-0434
local.identifier.orcidhttps://orcid.org/0000-0003-3054-3316
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/abs/10.1177/1934578X1601100932

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