Increased insulin sensitivity in individuals with neurofibromatosis type 1
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Universidade Federal de Minas Gerais
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Objects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis
type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1
were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood
samples were collected for biochemical assessment. Homeostasis model assessment adiponectin
(HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin
ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between
the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher
in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were
significantly lower, although adiponectin levels were significantly higher than those in the controls.
Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated
hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated
with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin,
glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI
leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD,
and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower
occurrence of type 2 diabetes mellitus in patients with NF1
Abstract
Assunto
Nutrição, Neurofibromatoses, Glicemia, Diabetes mellitus, Insulin resistance
Palavras-chave
Neurofibromatosis type 1, Blood glucose, Diabetes mellitus, Insulin resistance
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Endereço externo
https://www.scielo.br/j/aem/a/pnCr3WjWc6PZTQ4P3zMvmMH/?lang=en