Increased insulin sensitivity in individuals with neurofibromatosis type 1

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dc.creatorAline Stangherlin Martins
dc.creatorAnn Kristine Jansen
dc.creatorLuiz Oswaldo Carneiro Rodrigues
dc.creatorCamila Maria Matos
dc.creatorMárcio Leandro Ribeiro de Souza
dc.creatorDébora Marques Miranda
dc.creatorNilton Alves Resende
dc.date.accessioned2023-07-18T20:20:20Z
dc.date.accessioned2025-09-09T00:28:38Z
dc.date.available2023-07-18T20:20:20Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.20945/2359-3997000000007
dc.identifier.issn2359-4292
dc.identifier.urihttps://hdl.handle.net/1843/56634
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsAcesso Aberto
dc.subjectNutrição
dc.subjectNeurofibromatoses
dc.subjectGlicemia
dc.subjectDiabetes mellitus
dc.subjectInsulin resistance
dc.subject.otherNeurofibromatosis type 1
dc.subject.otherBlood glucose
dc.subject.otherDiabetes mellitus
dc.subject.otherInsulin resistance
dc.titleIncreased insulin sensitivity in individuals with neurofibromatosis type 1
dc.typeArtigo de periódico
local.citation.epage39
local.citation.issue1
local.citation.spage34
local.citation.volume62
local.description.resumoObjects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1
local.identifier.orcidhttps://orcid.org/0000-0002-7081-8401
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE ENFERMAGEM APLICADA
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aem/a/pnCr3WjWc6PZTQ4P3zMvmMH/?lang=en

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