Cytotoxicity, biocompatibility, and biomineralization of the new high-plasticity mta material

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dc.creatorLuciano Tavares Angelo Cintra
dc.creatorFrancine Benetti
dc.creatorÍndia Olinta de Azevedo Queiroz
dc.creatorJuliana Maria de Araújo Lopes
dc.creatorSandra Helena Penha de Oliveira
dc.creatorGustavo Sivieri Araújo
dc.creatorJoão Eduardo Gomes-Filho
dc.date.accessioned2022-09-24T19:36:26Z
dc.date.accessioned2025-09-09T01:13:00Z
dc.date.available2022-09-24T19:36:26Z
dc.date.issued2017-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.joen.2016.12.018
dc.identifier.issn00992399
dc.identifier.urihttps://hdl.handle.net/1843/45470
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Endodontics
dc.rightsAcesso Restrito
dc.subjectMaterials testing
dc.subjectBiomineralization
dc.subject.otherBiocompatibility
dc.subject.otherBiomineralization ability
dc.subject.otherCytotoxicity
dc.subject.otherMineral trioxide aggregate
dc.titleCytotoxicity, biocompatibility, and biomineralization of the new high-plasticity mta material
dc.typeArtigo de periódico
local.citation.epage778
local.citation.issue5
local.citation.spage774
local.citation.volume43
local.description.resumoIntroduction: Mineral trioxide aggregate (MTA) has excellent biological properties, but its handling proper- ties have been criticized for both ProRoot MTA (Tulsa Dental Products, Tulsa, OK) and white MTA-Angelus (MTA-Ang; Angelus Ind ustria de Produtos Odon- tol ogicos S/A, Londrina, PR, Brazil). Angelus MTA HP (high plasticity) (Angelus Ind ustria de Produtos Odon- tol ogicos S/A) has been introduced recently. Considering the importance of biological properties of materials that will be in contact with the tissues, this study evaluated the cytotoxicity, biocompatibility, and biomineralization of MTA HP compared with white MTA-Ang. Methods: L929 fibroblast cell lines were cultured, and cell viability was assessed at 6, 24, 48, and 72 hours using the ala- mar Blue assay (Thermo Fisher Scientific, Waltham, MA). A subcutaneous implant test was performed with polyethylene tubes containing 1 of the materials or empty tubes (control) using 20 Wistar rats. After 7 and 30 days of implantation, the tubes with surrounding tis- sues were removed for analysis using hematoxylin-eosin or von Kossa stain or they remained unstained for obser- vation under polarized light. The results were statisti- cally analyzed (P < .05). Results: A significant increase in cell viability for MTA HP was observed after 24, 48, and 72 hours compared with the control (P < .05). At 72 hours, MTA HP exhibited a higher viability compared with white MTA-Ang (P < .05). His- tologic analysis performed at 7 days showed moderate inflammation and a thick fibrous capsule in all groups (P > .05). At 30 days, mild inflammation and a thin fibrous capsule were observed in all groups (P > .05). All materials had structures positive for von Kossa and birefringent to polarized light. Conclusions: MTA HP showed biocompatibility and biomineralization similar to MTA-Ang. In addition, MTA HP showed increased fibroblast cell viability compared with white MTA-Ang after a longer period
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0099239916310640?via%3Dihub

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