A genetic profile of refractory individuals with major depressive disorder and their responsiveness to transcranial magnetic stimulation
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Effective in treatment-resistant depression (TRD), repetitive transcranial magnetic stimulation (rTMS) presents a remission
rate between 30% and 40%. Although genetics could be one potential source of inter-individual variability in rTMS responsiveness,
few studies have sought to identify possible genetic basis of rTMS response [1,2]. Therefore, we used an extreme-phenotype design
in which we compared genome-wide allelic variation between rigorously defined rTMS responders and non-responders.
A total of 99 TRD patients provided informed consent and this study was approved by the Human Research and Ethics Committee
of the Alfred Hospital. All were submitted to a rTMS protocol and completed at least 18 sessions of 10 Hz at left dorsolateral prefrontal cortex (DLPFC). Clinical outcomes (responder or non-responder) were determined based on scores on the Montgomery Asberg
Depression Rating Scale (MADRS).
Abstract
Assunto
Aspectos genéticos, Depressão mental - Tratamento
Palavras-chave
Treatment-Resistant Depression (TRD), repetitive transcranial magnetic stimulation (rTMS), Genetic profile
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Endereço externo
https://www.brainstimjrnl.com/article/S1935-861X(20)30098-X/fulltext#%20