A genetic profile of refractory individuals with major depressive disorder and their responsiveness to transcranial magnetic stimulation

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dc.creatorNathália Gualberto Souza e Silva
dc.creatorEduardo S. Nicolau
dc.creatorKate Hoy
dc.creatorZiarih Hawi
dc.creatorMark Bellgrove
dc.creatorDébora Miranda
dc.creatorMarco Aurelio Romano Silva
dc.creatorPaul Fitzgerald
dc.date.accessioned2023-07-19T16:50:05Z
dc.date.accessioned2025-09-08T23:06:07Z
dc.date.available2023-07-19T16:50:05Z
dc.date.issued2020
dc.identifier.doihttps://doi.org/10.1016/j.brs.2020.04.019
dc.identifier.issn1935-861X
dc.identifier.urihttps://hdl.handle.net/1843/56692
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrain Simulation
dc.rightsAcesso Aberto
dc.subjectAspectos genéticos
dc.subjectDepressão mental - Tratamento
dc.subject.otherTreatment-Resistant Depression (TRD)
dc.subject.otherrepetitive transcranial magnetic stimulation (rTMS)
dc.subject.otherGenetic profile
dc.titleA genetic profile of refractory individuals with major depressive disorder and their responsiveness to transcranial magnetic stimulation
dc.typeArtigo de periódico
local.citation.epage1093
local.citation.issue4
local.citation.spage1091
local.citation.volume13
local.description.resumoEffective in treatment-resistant depression (TRD), repetitive transcranial magnetic stimulation (rTMS) presents a remission rate between 30% and 40%. Although genetics could be one potential source of inter-individual variability in rTMS responsiveness, few studies have sought to identify possible genetic basis of rTMS response [1,2]. Therefore, we used an extreme-phenotype design in which we compared genome-wide allelic variation between rigorously defined rTMS responders and non-responders. A total of 99 TRD patients provided informed consent and this study was approved by the Human Research and Ethics Committee of the Alfred Hospital. All were submitted to a rTMS protocol and completed at least 18 sessions of 10 Hz at left dorsolateral prefrontal cortex (DLPFC). Clinical outcomes (responder or non-responder) were determined based on scores on the Montgomery Asberg Depression Rating Scale (MADRS).
local.identifier.orcidhttps://orcid.org/0000-0002-7620-8719
local.identifier.orcidhttps://orcid.org/0000-0003-0694-9674
local.identifier.orcidhttps://orcid.org/0000-0002-0814-9112
local.identifier.orcidhttps://orcid.org/0000-0003-0186-8349
local.identifier.orcidhttps://orcid.org/0000-0002-7081-8401
local.identifier.orcidhttps://orcid.org/0000-0002-6558-4639
local.identifier.orcidhttps://orcid.org/0000-0003-4217-8096
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.brainstimjrnl.com/article/S1935-861X(20)30098-X/fulltext#%20

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