Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Divisão celular no gênero Corynebacterium: interação proteína-proteína e docking molecular de SepF e FtsZ no entendimento da citocinese em espécies patogênicas
Primeiro orientador
Membros da banca
Resumo
The genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets.
Abstract
Assunto
Divisão celular, Corynebacterium, Simulação de acoplamento molecular
Palavras-chave
Cell division, Corynebacterium, FtsZ, SepF, Molecular docking
Citação
Departamento
Curso
Endereço externo
https://www.scielo.br/j/aabc/a/QV8k6VjHz8XSzbp7dSjbM8H/?lang=en