Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species

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dc.creatorAlberto Fernandes de Oliveira Júnior
dc.creatorEdson Luiz Folador
dc.creatorAnne Cybelle Pinto Gomide
dc.creatorAristóteles Góes Neto
dc.creatorRebecca Alice Wattam
dc.creatorVasco Ariston de Carvalho Azevedo
dc.date.accessioned2023-06-16T20:59:47Z
dc.date.accessioned2025-09-09T00:49:10Z
dc.date.available2023-06-16T20:59:47Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.1590/0001-3765201820170385
dc.identifier.issn1678-2690
dc.identifier.urihttps://hdl.handle.net/1843/55031
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais da Academia Brasileira de Ciências
dc.rightsAcesso Aberto
dc.subjectDivisão celular
dc.subjectCorynebacterium
dc.subjectSimulação de acoplamento molecular
dc.subject.otherCell division
dc.subject.otherCorynebacterium
dc.subject.otherFtsZ
dc.subject.otherSepF
dc.subject.otherMolecular docking
dc.titleCell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
dc.title.alternativeDivisão celular no gênero Corynebacterium: interação proteína-proteína e docking molecular de SepF e FtsZ no entendimento da citocinese em espécies patogênicas
dc.typeArtigo de periódico
local.citation.epage2188
local.citation.issue2 supl 1
local.citation.spage2179
local.citation.volume90
local.description.resumoThe genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets.
local.identifier.orcidhttps://orcid.org/0000-0002-8222-4440
local.identifier.orcidhttps://orcid.org/0000-0002-6752-9334
local.identifier.orcidhttps://orcid.org/0000-0003-3948-5335
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.identifier.orcidhttps://orcid.org/0000-0001-6018-6490
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aabc/a/QV8k6VjHz8XSzbp7dSjbM8H/?lang=en

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