Aggressive intraosseous myofibroma of the maxilla: report of a rare case and literature review
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Myofibroma (MF) is a benign mesenchymal myofibroblast-derived tumor, which occurs most frequently in children, and rarely affects the maxilla. We reported a case of an aggressive intraosseous lesion found in the maxilla of a 9-year-old female child. Intraorally, the swelling extended from tooth 12 to 16, causing displacement of teeth 13, 14, and 15. Computed tomography revealed a large osteolytic lesion causing thinning and cortical erosion. Microscopically, the lesion showed a proliferation of spindle-shaped cells, with elongated nuclei and eosinophilic cytoplasm, arranged in interlaced fascicles. The immunohistochemical analysis revealed cytoplasmic positivity for α-SMA and HHF-35, and negativity for desmin, laminin, S-100, β-catenin, and CD34. Ki-67 was positive in 8% of tumor cells. The diagnosis was MF. Herein, we describe an additional case of central MF arising in the maxilla, including clinical, imaging, microscopical, and immunohistochemical features, as well as a review of the literature.
Abstract
Assunto
Jaw, Maxilla, Myofibroma, Pediatrics, Actins, Tooth, Tooth avulsion, Cell proliferation, Ki-67 antigen, Immunohistochemistry, Tomography
Palavras-chave
Jaws, Maxilla, Myofibroma, Pediatrics
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https://link.springer.com/article/10.1007/s12105-020-01162-y