Aggressive intraosseous myofibroma of the maxilla: report of a rare case and literature review

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dc.creatorJohn Lennon Silva Cunha
dc.creatorCarla Isabelly Rodrigues Fernandes
dc.creatorCiro Dantas Soares
dc.creatorCeleste Sanchéz-Romero
dc.creatorPablo Agustin Vargas
dc.creatorCleverson Luciano Trento
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorSílvia Ferreira de Sousa
dc.creatorRicardo Luiz Cavalcanti de Albuquerque Junior
dc.date.accessioned2025-08-27T20:09:03Z
dc.date.accessioned2025-09-08T23:51:28Z
dc.date.available2025-08-27T20:09:03Z
dc.date.issued2021-03
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s12105-020-01188-2
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/84636
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectJaw
dc.subjectMaxilla
dc.subjectMyofibroma
dc.subjectPediatrics
dc.subjectActins
dc.subjectTooth
dc.subjectTooth avulsion
dc.subjectCell proliferation
dc.subjectKi-67 antigen
dc.subjectImmunohistochemistry
dc.subjectTomography
dc.subject.otherJaws
dc.subject.otherMaxilla
dc.subject.otherMyofibroma
dc.subject.otherPediatrics
dc.titleAggressive intraosseous myofibroma of the maxilla: report of a rare case and literature review
dc.typeArtigo de periódico
local.citation.epage310
local.citation.issue1
local.citation.spage301
local.citation.volume15
local.description.resumoMyofibroma (MF) is a benign mesenchymal myofibroblast-derived tumor, which occurs most frequently in children, and rarely affects the maxilla. We reported a case of an aggressive intraosseous lesion found in the maxilla of a 9-year-old female child. Intraorally, the swelling extended from tooth 12 to 16, causing displacement of teeth 13, 14, and 15. Computed tomography revealed a large osteolytic lesion causing thinning and cortical erosion. Microscopically, the lesion showed a proliferation of spindle-shaped cells, with elongated nuclei and eosinophilic cytoplasm, arranged in interlaced fascicles. The immunohistochemical analysis revealed cytoplasmic positivity for α-SMA and HHF-35, and negativity for desmin, laminin, S-100, β-catenin, and CD34. Ki-67 was positive in 8% of tumor cells. The diagnosis was MF. Herein, we describe an additional case of central MF arising in the maxilla, including clinical, imaging, microscopical, and immunohistochemical features, as well as a review of the literature.
local.identifier.orcidhttps://orcid.org/0000-0002-0679-8485
local.identifier.orcidhttps://orcid.org/0000-0002-1290-6235
local.identifier.orcidhttps://orcid.org/0000-0002-6861-6640
local.identifier.orcidhttps://orcid.org/0000-0001-5365-2692
local.identifier.orcidhttps://orcid.org/0000-0003-1840-4911
local.identifier.orcidhttps://orcid.org/0000-0002-1079-4217
local.identifier.orcidhttps://orcid.org/0000-0002-3259-606X
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0003-4444-7632
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-020-01162-y

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