ACP1 gene polymorphism associated with suicide attempt type in bipolar disorder patients.
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
The ACP1 gene is expressed in fetal and adult brain, and belongs to a phosphotyrosine protein phosphatase family
that acts regulating β-catenin levels. Increased amounts of ACP1 result in decreased β-catenin in the cytoplasm,1 which is the opposite effect of the administration of lithium. For these reasons the ACP1 seems a candidate gene to be associ ated both to bipolar disorder as well suicide behavior.A recent Genome-Wide association study of attempt sui cide in bipolar patients found a significantly association with the 2p25 region which SNPs fall in a large linkage disequilib rium with a block containing the acid phosphatase 1 (ACP1) gene region. Furthermore a microarray study show ACP1 levels significantly increased in the brains of patients who committed suicide.2The aim of our study was to evaluate whether ACP1 gene polymorphisms are associated to BD and/or suicide attempt in bipolar disorder patients in a different population sample.
Abstract
Assunto
Polimorfismo Genético, Suicídio, Transtorno Bipolar
Palavras-chave
Gene Polymorphism, Suicide, Bipolar Disorder
Citação
Curso
Endereço externo
https://www.psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2017.14.6.909