ACP1 gene polymorphism associated with suicide attempt type in bipolar disorder patients.

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dc.creatorSimone Becho de Campos
dc.creatorPaulo Marcos Brasil Rocha
dc.creatorFernando Silva Neves
dc.creatorDebora Marques Miranda
dc.creatorHumberto Corrêa da Silva Filho
dc.date.accessioned2023-07-12T21:41:21Z
dc.date.accessioned2025-09-09T00:56:56Z
dc.date.available2023-07-12T21:41:21Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.4306/pi.2017.14.6.909
dc.identifier.issn17383684
dc.identifier.urihttps://hdl.handle.net/1843/56150
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPsychiatry Investigation
dc.rightsAcesso Aberto
dc.subjectPolimorfismo Genético
dc.subjectSuicídio
dc.subjectTranstorno Bipolar
dc.subject.otherGene Polymorphism
dc.subject.otherSuicide
dc.subject.otherBipolar Disorder
dc.titleACP1 gene polymorphism associated with suicide attempt type in bipolar disorder patients.
dc.typeArtigo de periódico
local.citation.epage910
local.citation.issue6
local.citation.spage909
local.citation.volume14
local.description.resumoThe ACP1 gene is expressed in fetal and adult brain, and belongs to a phosphotyrosine protein phosphatase family that acts regulating β-catenin levels. Increased amounts of ACP1 result in decreased β-catenin in the cytoplasm,1 which is the opposite effect of the administration of lithium. For these reasons the ACP1 seems a candidate gene to be associ ated both to bipolar disorder as well suicide behavior.A recent Genome-Wide association study of attempt sui cide in bipolar patients found a significantly association with the 2p25 region which SNPs fall in a large linkage disequilib rium with a block containing the acid phosphatase 1 (ACP1) gene region. Furthermore a microarray study show ACP1 levels significantly increased in the brains of patients who committed suicide.2The aim of our study was to evaluate whether ACP1 gene polymorphisms are associated to BD and/or suicide attempt in bipolar disorder patients in a different population sample.
local.identifier.orcidhttps://orcid.org/0000-0003-2757-1375
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2017.14.6.909

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