Plasma and cerebrospinal fluid levels of cytokines as disease markers of neurologic manifestation in long-term HTLV-1 infected individuals
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Aim: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses. Materials & methods: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms. Results: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms. Conclusion: Different cytokines’ expression profile in the presence of neurological symptoms may help to understand and characterize the progression for severe clinical presentations.
Abstract
Assunto
Antigenos, Anticorpos, Líquido cefalorraquidiano, Paraparesia espástica tropical, Infecção por HTLV-1, Citocinas, Músculos - Doenças, Plasma
Palavras-chave
Antigens and antibodies, Cerebrospinal fluid, HAM / TSP, HTL, Immune markers, ITAC, Myopathy, Neurological symptoms, Plasma
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https://www.futuremedicine.com/doi/10.2217/bmm-2017-0313?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed