Plasma and cerebrospinal fluid levels of cytokines as disease markers of neurologic manifestation in long-term HTLV-1 infected individuals

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dc.creatorDaniela Valadão Freitas Rosa
dc.creatorLuiz Alexandre Viana Magno
dc.creatorNathália Cristina Moreira Pereira
dc.creatorLuiz Cláudio Ferreira Romanelli
dc.creatorMaicon Rodrigues Albuquerque
dc.creatorMarina Lobato Martins de Oliveira
dc.creatorAnna Barbara de Freitas Carneiro Proietti
dc.creatorRodrigo Nicolato
dc.creatorAna Cristina Simões e Silva
dc.creator‪Débora Marques de Miranda
dc.date.accessioned2023-02-28T14:39:32Z
dc.date.accessioned2025-09-09T00:28:35Z
dc.date.available2023-02-28T14:39:32Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.2217/bmm-2017-0313
dc.identifier.issn1752-0371
dc.identifier.urihttps://hdl.handle.net/1843/50509
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomarkers in Medicine
dc.rightsAcesso Restrito
dc.subjectAntigenos
dc.subjectAnticorpos
dc.subjectLíquido cefalorraquidiano
dc.subjectParaparesia espástica tropical
dc.subjectInfecção por HTLV-1
dc.subjectCitocinas
dc.subjectMúsculos - Doenças
dc.subjectPlasma
dc.subject.otherAntigens and antibodies
dc.subject.otherCerebrospinal fluid
dc.subject.otherHAM / TSP
dc.subject.otherHTL
dc.subject.otherImmune markers
dc.subject.otherITAC
dc.subject.otherMyopathy
dc.subject.otherNeurological symptoms
dc.subject.otherPlasma
dc.titlePlasma and cerebrospinal fluid levels of cytokines as disease markers of neurologic manifestation in long-term HTLV-1 infected individuals
dc.typeArtigo de periódico
local.citation.epage454
local.citation.issue5
local.citation.spage447
local.citation.volume12
local.description.resumoAim: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses. Materials & methods: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms. Results: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms. Conclusion: Different cytokines’ expression profile in the presence of neurological symptoms may help to understand and characterize the progression for severe clinical presentations.
local.identifier.orcidhttps://orcid.org/0000-0003-3693-1897
local.identifier.orcidhttp://orcid.org/0000-0001-6021-8480
local.identifier.orcidhttps://orcid.org/0000-0001-9222-3882
local.identifier.orcidhttps://orcid.org/0000-0002-7081-8401
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.futuremedicine.com/doi/10.2217/bmm-2017-0313?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

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