Dna methylation patterns of immune response-related genes in inflammatory external root resorption

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dc.creatorDaniela Augusta Barbato-Ferreira
dc.creatorSara Ferreira Dos Santos Costa
dc.creatorRicardo Santiago Gomez
dc.creatorJuliana Vilela Bastos
dc.date.accessioned2022-12-23T12:06:29Z
dc.date.accessioned2025-09-09T00:14:29Z
dc.date.available2022-12-23T12:06:29Z
dc.date.issued2020-08-07
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2020.vol34.0087
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/48413
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectEpigenomics
dc.subjectMethylation
dc.subjectInflammation
dc.subjectReplantation
dc.subjectRoot resorption
dc.subjectTooth extraction
dc.subject.otherEpigenomics
dc.subject.otherMethylation
dc.subject.otherInflammation
dc.subject.otherReplantation
dc.subject.otherRoot resorption
dc.titleDna methylation patterns of immune response-related genes in inflammatory external root resorption
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume34
local.description.resumoAbstract: Inflammatory external root resorption (IERR) is a pathological process defined by the progressive loss of dental hard tissue, dentin, and cementum, resulting from the combination of the loss of external root protective apparatus and root canal infection. It has been suggested that healing patterns after tooth replantation may be influenced by the genetic and immunological profiles of the patients. The purpose of the present investigation was to evaluate the DNA methylation patterns of 22 immune response-related genes in extracted human teeth presenting with IERR. Methylation assays were performed on samples of root fragments showing IERR and compared with healthy bone tissue collected during the surgical extraction of impacted teeth. The methylation patterns were quantified using EpiTect Methyl II Signature Human Cytokine Production PCR Array. The results revealed significantly higher hypermethylation of the FOXP3 gene promoter in IERR (65.95%) than in the bone group (23.43%) (p < 0.001). The ELANE gene was also highly methylated in the pooled IERR sample, although the difference was not statistically significant (p= 0.054). Our study suggests that the differential methylation patterns of immune response-related genes, such as FOXP3 and ELANE, may be involved in IERR modulation, and this could be related to the presence of root canal infection. However, further studies are needed to corroborate these findings to determine the functional relevance of these alterations and their role in the pathogenesis of IERR.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/34YhKTPhSWG3HVmZPKBMfdv/?lang=en

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