Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Senescence is a common denominator in wound healing, fibrosis, and cancer. Although, senescence is transiently antifibrotic, when prolonged, promotes fibrosis and malignant transformation. Eligible studies indexed in MEDLINE, Embase and Web of Science were searched to understand the role of cellular senescence in the pathogenesis of oral submucous fibrosis (OSF) and its malignant transformation. The senescence-associated secretory phenotype (SASP) components like IL-1, IL-6, and GRO-α induce double-strand DNA breaks in keratinocytes and drive genetic instability. SASP derived from myofibroblasts induces epithelial-mesenchymal transition in OSF and facilitates cancer progression. The use of senolytics has been shown to eliminate senescent cells from the areas of fibrosis, thereby preventing malignancy. Naturally occurring agents such as apigenin and kaempferol inhibit SASP. Mechanistic insight into the emerging role of senescence in the pathogenesis of OSF and modalities to inhibit senescence-associated antiapoptotic pathways as a supplementary therapy to prevent malignant transformation of OSF is underlined.
Abstract
Assunto
Cellular senescence, Myofibroblasts, Mouth neoplasms, Oral submucous fibrosis, Senescence-associated secretory phenotype, Apigenin
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carcinoma epidermoideacesso restrito fao clínica busca dia 29 do 11 de 2023 Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation assunto Cellular Senescence, título periódico Head and neck-journal for the sciences and specialties of the head and neck
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https://onlinelibrary.wiley.com/doi/10.1002/hed.26805