Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

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dc.creatorKeith Hunter
dc.creatorFelipe Paiva Fonseca
dc.creatorRaghu Radhakrishnan
dc.creatorMohit Sharma
dc.date.accessioned2023-12-14T19:26:44Z
dc.date.accessioned2025-09-09T00:28:07Z
dc.date.available2023-12-14T19:26:44Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1002/hed.26805
dc.identifier.issn10433074
dc.identifier.urihttps://hdl.handle.net/1843/61994
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and neck-journal for the sciences and specialties of the head and neck
dc.rightsAcesso Restrito
dc.subjectCellular senescence
dc.subjectMyofibroblasts
dc.subjectMouth neoplasms
dc.subjectOral submucous fibrosis
dc.subjectSenescence-associated secretory phenotype
dc.subjectApigenin
dc.subject.othercarcinoma epidermoideacesso restrito fao clínica busca dia 29 do 11 de 2023 Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation assunto Cellular Senescence
dc.subject.othertítulo periódico Head and neck-journal for the sciences and specialties of the head and neck
dc.titleEmerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation
dc.typeArtigo de periódico
local.citation.epage3164
local.citation.spage3153
local.citation.volume43
local.description.resumoSenescence is a common denominator in wound healing, fibrosis, and cancer. Although, senescence is transiently antifibrotic, when prolonged, promotes fibrosis and malignant transformation. Eligible studies indexed in MEDLINE, Embase and Web of Science were searched to understand the role of cellular senescence in the pathogenesis of oral submucous fibrosis (OSF) and its malignant transformation. The senescence-associated secretory phenotype (SASP) components like IL-1, IL-6, and GRO-α induce double-strand DNA breaks in keratinocytes and drive genetic instability. SASP derived from myofibroblasts induces epithelial-mesenchymal transition in OSF and facilitates cancer progression. The use of senolytics has been shown to eliminate senescent cells from the areas of fibrosis, thereby preventing malignancy. Naturally occurring agents such as apigenin and kaempferol inhibit SASP. Mechanistic insight into the emerging role of senescence in the pathogenesis of OSF and modalities to inhibit senescence-associated antiapoptotic pathways as a supplementary therapy to prevent malignant transformation of OSF is underlined.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/hed.26805

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