Natural and artificial knitted fabrics functionalized with Cordia curassavica accelerate excisional wound healing in mice
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Universidade Federal de Minas Gerais
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The present study evaluated the efects of natural and artifcial knitted fabrics functionalized with Cordia curassavica (Jacq.)
Roem. & Schult., Boraginaceae, in the skin wound healing process induced in mice. C57BL/6 male mouse wounds were
treated as follows: polylactic acid fber; polylactic acid fber + C. curassavica oil; cotton; and cotton + C. curassavica oil.
The wound closure kinetics, histological analysis, and fbronectin mRNA expression were evaluated after 3, 5, 7, and 14 days
of treatment. The wound closure kinetics area under the curve analysis evidenced the polylactic acid fber + oil treatment
accelerating the wound closure as compared to other groups (cotton: 541.7 ± 37.73; cotton + oil: 720.4 ± 27.88; polylactic
acid fber: 536.8 ± 33.89; polylactic acid fber + oil: 945.7 ± 33.52). The skin wounds treated with functionalized fabrics
showed a proper wound healing resolution, normal granulation tissue architecture and cell infltrate, a lower number of
mastocytes, a higher collagen deposition, and increased fbronectin mRNA expression levels. In summary, we report for the
frst time that the polylactic acid fber accelerates the wound healing process, an efect potentialized by the C. curassavica
volatile oil. These fndings point to the polylactic acid fber + oil as an important alternative therapeutic approach to improve
wound healing treatment.
Abstract
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Cicatrização de feridas, Cura, Matéria médica vegetal, Plantas medicinais
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https://link.springer.com/article/10.1007/s43450-021-00225-7