Natural and artificial knitted fabrics functionalized with Cordia curassavica accelerate excisional wound healing in mice

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dc.creatorJanaina Ribeiro Oliveira
dc.creatorAndré Luiz Senna Guimarães
dc.creatorLucyana Conceição Farias
dc.creatorFernanda Steffens
dc.creatorFernando Ribeiro Oliveira
dc.creatorSergio Henrique Sousa Santos
dc.creatorAmanda Souto Machado
dc.creatorDeborah de Farias Lelis
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorLuis Paulo Oliveira
dc.creatorSidnei Tavares Reis
dc.creatorTheles Oliveira Costa
dc.creatorClaudia Regina Vieira
dc.creatorAlfredo Mauricio Batista de Paula
dc.date.accessioned2023-11-09T15:21:22Z
dc.date.accessioned2025-09-08T23:27:24Z
dc.date.available2023-11-09T15:21:22Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s43450-021-00225-7
dc.identifier.issn0102-695X
dc.identifier.urihttps://hdl.handle.net/1843/60709
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.rightsAcesso Restrito
dc.subjectCicatrização de feridas
dc.subjectCura
dc.subjectMatéria médica vegetal
dc.subjectPlantas medicinais
dc.titleNatural and artificial knitted fabrics functionalized with Cordia curassavica accelerate excisional wound healing in mice
dc.typeArtigo de periódico
local.citation.epage98
local.citation.spage86
local.citation.volume32
local.description.resumoThe present study evaluated the efects of natural and artifcial knitted fabrics functionalized with Cordia curassavica (Jacq.) Roem. & Schult., Boraginaceae, in the skin wound healing process induced in mice. C57BL/6 male mouse wounds were treated as follows: polylactic acid fber; polylactic acid fber + C. curassavica oil; cotton; and cotton + C. curassavica oil. The wound closure kinetics, histological analysis, and fbronectin mRNA expression were evaluated after 3, 5, 7, and 14 days of treatment. The wound closure kinetics area under the curve analysis evidenced the polylactic acid fber + oil treatment accelerating the wound closure as compared to other groups (cotton: 541.7 ± 37.73; cotton + oil: 720.4 ± 27.88; polylactic acid fber: 536.8 ± 33.89; polylactic acid fber + oil: 945.7 ± 33.52). The skin wounds treated with functionalized fabrics showed a proper wound healing resolution, normal granulation tissue architecture and cell infltrate, a lower number of mastocytes, a higher collagen deposition, and increased fbronectin mRNA expression levels. In summary, we report for the frst time that the polylactic acid fber accelerates the wound healing process, an efect potentialized by the C. curassavica volatile oil. These fndings point to the polylactic acid fber + oil as an important alternative therapeutic approach to improve wound healing treatment.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s43450-021-00225-7

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