Immunoexpression of SOX-2 in oral leukoplakia
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Objective: This study was conducted to correlate and compare the immunoexpression of sex-determining region Y-box 2 (SOX-2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control).
Materials and methods: In this observational study, OL with low-risk (n = 34) and high-risk (n = 33) dysplasia and control samples (n = 25) were subjected to immunohistochemical analysis for SOX-2. In the epithelium, SOX-2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted. Statistical tests included chi-square, one-way analysis of variance, Tukey, and Games-Howell. The level of significance was 5%.
Results: Groups with OL lesions (low and high-risk) showed higher mean numbers of SOX-2 positive cells (63.47 ± 25.70 and 68.18 ± 21.17) compared to the control group (45.85 ± 27.38) (p = 0.00). Groups with OL lesions (low and high-risk) exhibited higher mean positive nuclear area (0.24 ± 0.47 and 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) (p = 0.01).
Conclusion: Oral leukoplakia lesions showed a higher expression of SOX-2, suggesting its contribution to the pathogenesis of OL.
Abstract
Assunto
Mouth, Leukoplakia, Mouth neoplasms, SOXB2 transcription factors, Immunohistochemistry, Immune system, Gene expression
Palavras-chave
leukoplakia, immunohistochemistry, sox2
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https://onlinelibrary.wiley.com/doi/10.1111/odi.12922