Immunoexpression of SOX-2 in oral leukoplakia

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dc.creatorSuelen Teixeira Luiz
dc.creatorRafaela Scariot de Moraes
dc.creatorMaria Cassia Ferreira de Aguiar
dc.creatorSérgio Aparecido Ignácio
dc.creatorBruno Correia Jham
dc.creatorLucia de Noronha
dc.creatorAline Cristina Batista Rodrigues Johann
dc.creatorFilipe Modolo Siqueira
dc.creatorIzabela Mozzer
dc.creatorEmanuela Carla dos Santos
dc.creatorSeigo Nagashima
dc.creatorAna Paula Camargo Martins
dc.creatorMarina Luise Viola de Azevedo
dc.creatorLuciana Reis Azevedo Alanis
dc.creatorAna Maria Grégio Hardy
dc.date.accessioned2024-08-05T21:12:13Z
dc.date.accessioned2025-09-09T01:29:45Z
dc.date.available2024-08-05T21:12:13Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/odi.12922
dc.identifier.issn1601-0825
dc.identifier.urihttps://hdl.handle.net/1843/72668
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Restrito
dc.subjectMouth
dc.subjectLeukoplakia
dc.subjectMouth neoplasms
dc.subjectSOXB2 transcription factors
dc.subjectImmunohistochemistry
dc.subjectImmune system
dc.subjectGene expression
dc.subject.otherleukoplakia
dc.subject.otherimmunohistochemistry
dc.subject.othersox2
dc.titleImmunoexpression of SOX-2 in oral leukoplakia
dc.typeArtigo de periódico
local.citation.epage1457
local.citation.issue8
local.citation.spage1449
local.citation.volume24 Oral diseases
local.description.resumoObjective: This study was conducted to correlate and compare the immunoexpression of sex-determining region Y-box 2 (SOX-2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control). Materials and methods: In this observational study, OL with low-risk (n = 34) and high-risk (n = 33) dysplasia and control samples (n = 25) were subjected to immunohistochemical analysis for SOX-2. In the epithelium, SOX-2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted. Statistical tests included chi-square, one-way analysis of variance, Tukey, and Games-Howell. The level of significance was 5%. Results: Groups with OL lesions (low and high-risk) showed higher mean numbers of SOX-2 positive cells (63.47 ± 25.70 and 68.18 ± 21.17) compared to the control group (45.85 ± 27.38) (p = 0.00). Groups with OL lesions (low and high-risk) exhibited higher mean positive nuclear area (0.24 ± 0.47 and 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) (p = 0.01). Conclusion: Oral leukoplakia lesions showed a higher expression of SOX-2, suggesting its contribution to the pathogenesis of OL.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.12922

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