Prognostic factors for metastasis in cutaneous melanoma
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
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Abstract: Background: Melanoma is a malignant neoplasia that shows high mortality when diagnosed in advanced stages. Early
identification of high-risk patients for the development of melanoma metastases is the main strategy to reduce mortality. oBjective: To assess the influence of eight epidemiological and histopathologic features on the development of metastases in patients diagnosed with primary cutaneous melanoma. Methods: Our historical cohort comprised patients with invasive primary cutaneous melanoma seen between 1995 and 2012 at a public university hospital and a private oncologic surgery institution in Southeastern Brazil. The following variables were
analyzed: gender, age, family history of melanoma, site of the primary tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and the mitotic index. Kaplan-Meier univariate test and multivariate Cox proportional hazard analysis were used to assess factors associated with disease-free survival. results: Five hundred and fourteen patients were enrolled. The univariate analysis identified the following significant risk factors:gender, age, site of the tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and mitotic index. Multivariate analysis included 244 patients and detected four significant prognostic factors: male gender, nodular clinical and histologic subtype, Breslow thickness > 4mm, and histologic ulceration. The mitotic index was not included in this analysis. study liMitations: Small number of patients in multivariate analysis.
conclusions: The following prognostic factors to the development of melanoma metastasis were identified in the study: male gender, nodular histologic subtype, Breslow thickness > 4mm and ulceration.
Abstract
Assunto
Melanoma, Skin Neoplasms
Palavras-chave
Melanoma, Skin cancers, Neoplastic metastasis
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http://dx.doi.org/10.1590/abd1806-4841.20184779