Prognostic factors for metastasis in cutaneous melanoma
| dc.creator | Ana Carolina Figueiredo Pereiracherobin | |
| dc.creator | Alberto Julius Alves Wainstein | |
| dc.creator | Enrico Antônio Colosimo | |
| dc.creator | Eugênio Marcos Andrade Goulart | |
| dc.creator | Flávia Vasques Bittencourt | |
| dc.date.accessioned | 2023-12-11T21:41:34Z | |
| dc.date.accessioned | 2025-09-09T01:29:13Z | |
| dc.date.available | 2023-12-11T21:41:34Z | |
| dc.date.issued | 2018 | |
| dc.format.mimetype | ||
| dc.identifier.doi | 10.1590/abd1806-4841.20184779 | |
| dc.identifier.issn | 18064841 | |
| dc.identifier.uri | https://hdl.handle.net/1843/61896 | |
| dc.language | eng | |
| dc.publisher | Universidade Federal de Minas Gerais | |
| dc.relation.ispartof | Anais Brasileiros de Dermatologia | |
| dc.rights | Acesso Aberto | |
| dc.subject | Melanoma | |
| dc.subject | Skin Neoplasms | |
| dc.subject.other | Melanoma | |
| dc.subject.other | Skin cancers | |
| dc.subject.other | Neoplastic metastasis | |
| dc.title | Prognostic factors for metastasis in cutaneous melanoma | |
| dc.type | Artigo de periódico | |
| local.citation.epage | 26 | |
| local.citation.issue | 1 | |
| local.citation.spage | 19 | |
| local.citation.volume | 93 | |
| local.description.resumo | Abstract: Background: Melanoma is a malignant neoplasia that shows high mortality when diagnosed in advanced stages. Early identification of high-risk patients for the development of melanoma metastases is the main strategy to reduce mortality. oBjective: To assess the influence of eight epidemiological and histopathologic features on the development of metastases in patients diagnosed with primary cutaneous melanoma. Methods: Our historical cohort comprised patients with invasive primary cutaneous melanoma seen between 1995 and 2012 at a public university hospital and a private oncologic surgery institution in Southeastern Brazil. The following variables were analyzed: gender, age, family history of melanoma, site of the primary tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and the mitotic index. Kaplan-Meier univariate test and multivariate Cox proportional hazard analysis were used to assess factors associated with disease-free survival. results: Five hundred and fourteen patients were enrolled. The univariate analysis identified the following significant risk factors:gender, age, site of the tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and mitotic index. Multivariate analysis included 244 patients and detected four significant prognostic factors: male gender, nodular clinical and histologic subtype, Breslow thickness > 4mm, and histologic ulceration. The mitotic index was not included in this analysis. study liMitations: Small number of patients in multivariate analysis. conclusions: The following prognostic factors to the development of melanoma metastasis were identified in the study: male gender, nodular histologic subtype, Breslow thickness > 4mm and ulceration. | |
| local.publisher.country | Brasil | |
| local.publisher.department | ICX - DEPARTAMENTO DE ESTATÍSTICA | |
| local.publisher.department | MED - DEPARTAMENTO DE CLÍNICA MÉDICA | |
| local.publisher.initials | UFMG | |
| local.url.externa | http://dx.doi.org/10.1590/abd1806-4841.20184779 |