Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties.
Abstract
Assunto
Câncer, Nanopartículas, Lipídios
Palavras-chave
Cancer, Sclareol, Solid lipid nanoparticles, Nanostructured lipid carriers, Small-angle X-ray scattering
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Endereço externo
https://www.scielo.br/j/bjps/a/hrgfv38NNnJqwvqXtQVG9Dv/?lang=en