Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines

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dc.creatorGabriel Silva Marques Borges
dc.creatorElaine Maria de Souza Fagundes
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorPedro Henrique Dias Moura Prazeres
dc.creatorÂngelo Malachias de Souza
dc.creatorMaria Irene Yoshida
dc.creatorJosé Mário Carneiro Vilela
dc.creatorAline Teixeira Maciel e Silva
dc.creatorMariana Silva Oliveira
dc.creatorDawidson Assis Gomes
dc.creatorMargareth Spangler Andrade
dc.date.accessioned2023-04-27T18:25:50Z
dc.date.accessioned2025-09-09T01:33:27Z
dc.date.available2023-04-27T18:25:50Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.1590/s2175-97902020000418497
dc.identifier.issn2175-9790
dc.identifier.urihttps://hdl.handle.net/1843/52599
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.rightsAcesso Aberto
dc.subjectCâncer
dc.subjectNanopartículas
dc.subjectLipídios
dc.subject.otherCancer
dc.subject.otherSclareol
dc.subject.otherSolid lipid nanoparticles
dc.subject.otherNanostructured lipid carriers
dc.subject.otherSmall-angle X-ray scattering
dc.titleNanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines
dc.typeArtigo de periódico
local.citation.epage15
local.citation.spage1
local.citation.volume57
local.description.resumoSclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties.
local.identifier.orcidhttps://orcid.org/0000-0002-7360-8231
local.identifier.orcidhttps://orcid.org/0000-0002-0539-9052
local.identifier.orcidhttps://orcid.org/0000-0003-2474-5536
local.identifier.orcidhttps://orcid.org/0000-0002-1933-3230
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0001-7714-991X
local.identifier.orcidhttps://orcid.org/0000-0002-0412-1622
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bjps/a/hrgfv38NNnJqwvqXtQVG9Dv/?lang=en

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