Efeito da lavagem da cavidade peritoneal com soluções salinas a 0,9% e a 3% na injúria pulmonar precoce de gerbis com peritonite induzida

Abstract

INTRODUCTION: Peritoneal cavity lavage is widely spread in the treatment of peritonitis. Nonetheless, some studies question its rationale and prove it to be deleterious to the mesothelium. OBJECTIVE: The present study aims to determine whether 0.9% and 3% saline lavage of the peritoneal cavity has an effect on early lung injury of gerbils with induced peritonitis. METHODOLOGY: Thirty four male gerbils were divided into four groups: Control (n=9), submitted to laparotomy at time zero, re-laparotomy after 2 h, and sacrifice after a total of 6 hours from start; Untreated (n=8), submitted to peritonitis induction through cecal ligation and puncture (CLP) at time zero, re-laparotomy intended for drying of abdominal cavity and resection of the ischemic cecum after 2 h, and sacrifice after a total of 6 h from start; Saline (n=8), submitted to peritonitis induction through CLP at time zero, relaparotomy intended for warm 0.9% saline lavage of the abdominal cavity and resection of the ischemic cecum after 2 h, and sacrifice after a total of 6 h from start; and Hypertonic (n=9), submitted to the same procedure as the saline group only using a 3% saline solution. After the sacrifice, we collected the left lung for morphometric analysis. RESULTS: In the saline and hypertonic group there was a significant decrease in the mean nuclei count in the lungs, when compared to the untreated group (p<0,01). CONCLUSION: The present study demonstrated that peritoneal lavage with warm 0.9% and 3% saline has a beneficial effect on the early systemic inflammatory response in septic gerbils, modulating and reducing the lung injury.