Efetividade do tratamento antirretroviral nas primeiras 48 semanas após seu início, Belo Horizonte, Minas Gerais - 2010 a 2013

Abstract

INTRODUCTION: After more than 30 years of the epidemic and despite great achievements, the impact of HIV/AIDS infection still represents a major problem worldwide, remaining a challenge to be overcome. METHOD: This is a cohort study that evaluates the effectiveness of antiretroviral therapy (ART) in the first year of its introduction. Only effectiveness was analyzed by measuring viral load (CV) 48 weeks after initiation. Changes related to intolerance and adverse events were not considered therapeutic failure. The study was conducted at the Reference Service for Infectious and Parasitic Diseases (CTR/DIP) Orestes Diniz, in Belo Horizonte, MG, between October 2010 and January 2013. A total of 182 patients who met the inclusion criteria were included. RESULTS: There was a predominance of males, mostly under 50 years of age. A high prevalence of groups of greater vulnerability to exposure to HIV was found, such as men who have sex with men, who represented 43.4% of the study sample. The overall effectiveness, as assessed by the proportion of CV < limit of detection, was 91% (166/182). Univariate and multivariate analyzes found no association between studied variables and treatment effectiveness. CONCLUSION: There was a high therapeutic success rate evaluated through VC, however the great challenge is the maintenance of individuals in the care and adherence to the treatment. Also noteworthy is the lower percentage of late initiation of ART compared to other Brazilian studies, however, still high compared to developed countries. Despite this, the immunovirological responses were superior to those described by the Ministry of Health and some efficacy studies.