Avaliação da concentração de dímero-D e o impacto de polimorfismos nos genes F3, F5 e FGA no prognóstico de pacientes hospitalizados com COVID-19

Abstract

COVID-19 is a disease caused by the SARS-CoV-2 virus, part of the family Coronaviridae. Disease prognosis is very heterogeneous and the cases very from asymptomatics to very serious, which can lead to death. The rise on the D-dimer levels in pacients that needed hospitalization sugests a dysregulation of the coagulation cascade caused by the virus. This study aimed to analyze the polymorphisms related to the coagulation and its association with COVID-19 severity, as well as investigate the correlation with the elevated D-dimer levels. We had evaluated the polymorphisms rs13109457, rs12029080 and rs6687813, presente in the genes FGG, FGA, F3, F5 and Z99572.1 in a sample of 217 patients, all hospitalized in the period between 2020 July and 2022 March in the Eduardo Menezes Hospital. The models of codominance and dominance of the allele A for the polymorphism rs6687813 and the average hospitalization time were significant. Highlighting that the individuals with the genotype C/C preseted a longer average hospitalization time (p=0.04 and p=0.02, respectively). The recessive model for the A allele of the rs13109457 polymorphism also showed significant for the hospitalization time (p=0.04). Patients who died showed median age lower than survivors (p=0.02). The collect year showed significance for the mechanical ventilation use (p=0.04), as well as 71% of the self declared brown individuals that required ventilatory support (p=0.02). The results of this study demonstrate the importance of the genetic monitoring for the early identification of patients with higher risk of bad prognosis. Studies about the disease evolution are important to analyse the progression and dissemination of the disease providing answers for public health problems.