Comparison between enzyme immunoassays performed on samples of dried blood and serum for toxoplasmosis prenatal screening: population-based study

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dc.creatorBárbara Araújo Marques
dc.creatorEricka v m Carellos
dc.creatorVânia Maria Nonato Silva
dc.creatorFernando Henrique Pereira
dc.creatorMaria Regina Lage Guerra
dc.creatorJacqueline Araújo Domingos Iturra
dc.creatorJosé Nelio Januario
dc.creatorGláucia Manzan Queiroz Andrade
dc.date.accessioned2023-06-30T17:54:04Z
dc.date.accessioned2025-09-09T00:12:34Z
dc.date.available2023-06-30T17:54:04Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1055/s-0041-1730285
dc.identifier.issn18069339
dc.identifier.urihttps://hdl.handle.net/1843/55639
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRBGO Gynecology and Obstetrics
dc.rightsAcesso Aberto
dc.subjectMedicina
dc.subject.otherPrenatal
dc.subject.otherCongenital
dc.titleComparison between enzyme immunoassays performed on samples of dried blood and serum for toxoplasmosis prenatal screening: population-based study
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage1
local.citation.volume1
local.description.resumoObjective Most prenatal screening programs for toxoplasmosis use immunoassays in serum samples of pregnant women. Few studies assess the accuracy of screening tests in dried blood spots, which are of easy collection, storage, and transportation. The goals of the present study are to determine the performance and evaluate the agreement between an immunoassay of dried blood spots and a reference test in the serum of pregnant women from a population-based prenatal screening program for toxoplasmosis in Brazil. Methods A cross-sectional study was performed to compare the immunoassays Imunoscreen Toxoplasmose IgM and Imunoscreen Toxoplasmose IgG (Mbiolog Diagnósticos, Ltda., Contagem, Minas Gerais, Brazil)in dried blood spots with the enzymelinked fluorescent assay (ELFA, BioMérieux S.A., Lyon, France) reference standard in the serum of pregnant women from Minas Gerais Congenital Toxoplasmosis Control Program. Results The dried blood spot test was able to discriminate positive and negative results of pregnant women when comparedwith the reference test, with an accuracy of 98.2% for immunoglobulin G (IgG), and of 95.8% for immunoglobulin M (IgM). Conclusion Dried blood samples are easy to collect, store, and transport, and they have a good performance,making this a promisingmethod for prenatal toxoplasmosis screening programs in countries with continental dimensions, limited resources, and a high prevalence of toxoplasmosis, as is the case of Brazil.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://lp.thieme.de/journals/rbgo-gynecology-und-obstetrics/0100-7203

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