Positively-charged electrosprayed nanoparticles based on biodegradable polymers containing amphotericin B for the treatment of leishmaniasis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Poly(Ɛ-caprolactone) (PCL) electrosprayed nanoparticles (NPs) containing Amphotericin B (AMB) were prepared for the treatment of leishmaniasis. Two variations of PCL nanoparticles with positive surface charges, which can enhance cell uptake and restrict agglomeration, were produced: (1) NPs containing stearylamine and (2) core-shell nanoparticles, with chitosan in the shell and PCL and AMB in the core. The results proved the viability of producing positively charged PCL nanoparticles with AMB, with diameters <350nm. The encapsulation efficiency of the drug was higher than 75%. The electrosprayed nanoparticles containing AMB were much less cytotoxic to cells than that of pure AMB.
Abstract
Assunto
Anfotericina B., Leishmaniose, Nanopartículas
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Amphotericin B, Coaxial electrospraying, Core-shell nanoparticles, Leishmaniasis, Nanoparticles, Poly(Ɛ -caprolactone)
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https://www.tandfonline.com/doi/full/10.1080/00914037.2020.1785457