Positively-charged electrosprayed nanoparticles based on biodegradable polymers containing amphotericin B for the treatment of leishmaniasis

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dc.creatorManuela Maria de Sousa Messeder
dc.creatorDiego Miranda
dc.creatorSarah Oliveira Lamas de Souza
dc.creatorMatheus Figueiredo Dorneles
dc.creatorRodolfo Cordeiro Giunchetti
dc.creatorRodrigo Lambert Oréfice
dc.date.accessioned2023-06-15T21:31:43Z
dc.date.accessioned2025-09-09T01:08:13Z
dc.date.available2023-06-15T21:31:43Z
dc.date.issued2020
dc.identifier.doihttps://doi.org/10.1080/00914037.2020.1785457
dc.identifier.issn00914037
dc.identifier.urihttps://hdl.handle.net/1843/54982
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.rightsAcesso Restrito
dc.subjectAnfotericina B.
dc.subjectLeishmaniose
dc.subjectNanopartículas
dc.subject.otherAmphotericin B
dc.subject.otherCoaxial electrospraying
dc.subject.otherCore-shell nanoparticles
dc.subject.otherLeishmaniasis
dc.subject.otherNanoparticles
dc.subject.otherPoly(Ɛ -caprolactone)
dc.titlePositively-charged electrosprayed nanoparticles based on biodegradable polymers containing amphotericin B for the treatment of leishmaniasis
dc.typeArtigo de periódico
local.citation.epage1202
local.citation.issue16
local.citation.spage1190
local.citation.volume70
local.description.resumoPoly(Ɛ-caprolactone) (PCL) electrosprayed nanoparticles (NPs) containing Amphotericin B (AMB) were prepared for the treatment of leishmaniasis. Two variations of PCL nanoparticles with positive surface charges, which can enhance cell uptake and restrict agglomeration, were produced: (1) NPs containing stearylamine and (2) core-shell nanoparticles, with chitosan in the shell and PCL and AMB in the core. The results proved the viability of producing positively charged PCL nanoparticles with AMB, with diameters <350nm. The encapsulation efficiency of the drug was higher than 75%. The electrosprayed nanoparticles containing AMB were much less cytotoxic to cells than that of pure AMB.
local.identifier.orcidhttps://orcid.org/0000-0002-3349-5762
local.identifier.orcidhttps://orcid.org/0000-0003-4181-7546
local.identifier.orcidhttps://orcid.org/0000-0002-6046-4056
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/full/10.1080/00914037.2020.1785457

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