A case series of adenomatoid odontogenic tumor: clinicopathologic and molecular characterization
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Universidade Federal de Minas Gerais
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Artigo de periódico
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We report a series of 22 adenomatoid odontogenic tumors
(AOTs). The patients’ age, tumor location, association with
impacted teeth, and clinical size were obtained. Capsule thick
ness was evaluated. The patients’ mean age was 18.8 years
(range 6-57 y). Considering the cases with known information,
16 occurred in women and 5 in men, 11 in the maxilla, and 10 in
the mandible, 13 in the anterior regions, and 7 in the posterior
regions, 8 in association with impacted teeth, and 9 not associ
ated with impaction. We evaluated 3 AOT samples for mutations
in a panel of 50 oncogenes and tumor suppressor genes by next
generation sequencing. The KRAS G12V mutation was detected
in 3 samples. We screened the other 19 samples for KRAS codon
12 mutations. KRAS codon 12 mutations occurred in 15 out of 22
(68%), KRAS G12V in 14 out of 22 cases, and KRAS G12R in 1
out of 22. Codon 12 mutations were not associated with any of
the clinicopathologic parameters tested (P > .05).
Abstract
Assunto
Genes, tumor suppressor, Codon, Mutation, Maxilla, Mandible, Tooth, Odontogenic tumors, Adenomatoid tumor
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https://www.sciencedirect.com/science/article/pii/S2212440319305966