A case series of adenomatoid odontogenic tumor: clinicopathologic and molecular characterization

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dc.creatorCarolina Cavaliéri Gomes
dc.creatorBruna Pizziolo Coura
dc.creatorSílvia Ferreira de Sousa
dc.creatorVanessa de Fátima Bernardes
dc.creatorJosiane Alves França
dc.creatorMarina Gonçalves Diniz
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-08-25T19:52:22Z
dc.date.accessioned2025-09-09T01:12:08Z
dc.date.available2025-08-25T19:52:22Z
dc.date.issued2020-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2019.06.047
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/84554
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectGenes, tumor suppressor
dc.subjectCodon
dc.subjectMutation
dc.subjectMaxilla
dc.subjectMandible
dc.subjectTooth
dc.subjectOdontogenic tumors
dc.subjectAdenomatoid tumor
dc.titleA case series of adenomatoid odontogenic tumor: clinicopathologic and molecular characterization
dc.typeArtigo de periódico
local.citation.epagee24
local.citation.issue1
local.citation.spagee24
local.citation.volume129
local.description.resumoWe report a series of 22 adenomatoid odontogenic tumors (AOTs). The patients’ age, tumor location, association with impacted teeth, and clinical size were obtained. Capsule thick ness was evaluated. The patients’ mean age was 18.8 years (range 6-57 y). Considering the cases with known information, 16 occurred in women and 5 in men, 11 in the maxilla, and 10 in the mandible, 13 in the anterior regions, and 7 in the posterior regions, 8 in association with impacted teeth, and 9 not associ ated with impaction. We evaluated 3 AOT samples for mutations in a panel of 50 oncogenes and tumor suppressor genes by next generation sequencing. The KRAS G12V mutation was detected in 3 samples. We screened the other 19 samples for KRAS codon 12 mutations. KRAS codon 12 mutations occurred in 15 out of 22 (68%), KRAS G12V in 14 out of 22 cases, and KRAS G12R in 1 out of 22. Codon 12 mutations were not associated with any of the clinicopathologic parameters tested (P > .05).
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0002-9987-5311
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0003-0194-7434
local.identifier.orcidhttps://orcid.org/0000-0002-6005-783X
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440319305966

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