Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
The treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC.
Abstract
Assunto
Candidíase vulvovaginal, Ácido hialurônico, Anfotericina B, Nanopartículas Eudragit RL100
Palavras-chave
Eudragit RL100, Amphotericin B, Hyaluronic acid, Amphotericin B-loaded eudragit RL100 nanoparticles coated with hyaluronic acid, Vulvovaginal candidiasis
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https://www.sciencedirect.com/science/article/pii/S0144861719312767#!