Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis

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dc.creatorCarolina Mirtes Melo
dc.creatorJéssica Ferreira Cardoso
dc.creatorFernanda Barçante Perassoli
dc.creatorAri Soares de Oliveira Neto
dc.creatorLuccas Moreira Pinto
dc.creatorMaria Betânia de Freitas Marques
dc.creatorWagner da Nova Mussel
dc.creatorJuliana Teixeira Magalhães
dc.creatorSandra Aparecida de Lima Moura
dc.creatorMarcelo Gonzaga de Freitas Araújo
dc.creatorGisele Rodrigues da Silva
dc.date.accessioned2022-05-20T20:08:29Z
dc.date.accessioned2025-09-09T01:19:39Z
dc.date.available2022-05-20T20:08:29Z
dc.date.issued2020-02-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1016/j.carbpol.2019.115608
dc.identifier.issn0144-8617
dc.identifier.urihttps://hdl.handle.net/1843/41863
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCarbohydrate Polymers
dc.rightsAcesso Restrito
dc.subjectCandidíase vulvovaginal
dc.subjectÁcido hialurônico
dc.subjectAnfotericina B
dc.subjectNanopartículas Eudragit RL100
dc.subject.otherEudragit RL100
dc.subject.otherAmphotericin B
dc.subject.otherHyaluronic acid
dc.subject.otherAmphotericin B-loaded eudragit RL100 nanoparticles coated with hyaluronic acid
dc.subject.otherVulvovaginal candidiasis
dc.titleAmphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume230
local.description.resumoThe treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0144861719312767#!

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