Use of cytological smear and cell block technique for the diagnosis of plasma cell myeloma infiltration in the mandible
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Fine-needle aspiration cytology (FNAC) is a diagnostic tool
using a needle to collect samples for cytopathological examina tion. We report a case of a 49-year-old male patient with previ ous medical history of plasma cell myeloma (PCM), who had
osteolytic lesions in the mandible, diagnosed by FNAC. Imaging
exams exhibited multiple osteolytic lesions with ill-defined mar gins in the bilateral mandibular body. FNAC of the intraosseous
lesion of the mandible was performed. Cytological smear and
cell block technique revealed plasma cells in different degrees of
maturation, predominantly eccentric pleomorphic nuclei and
abundant, eosinophilic cytoplasm without a paranuclear halo.
Immunohistochemistry exhibited positivity for CD138, lambda
light chain and Ki-67 (proliferation index was »50%). Based on
clinicoradiographic, microscopic, and biochemical findings, the
diagnosis was PCM infiltration in the mandible. The patient
underwent chemotherapy and autologous hematopoietic stem
cell transplantation, and had partial remission after 10 months of
follow-up.
Abstract
Assunto
Drug Therapy, Cytology, Diagnosis, Multiple myeloma, Hematopoietic stem cell transplantation, Syndecan-1, Ki-67 antigen, Immunohistochemistry
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https://www.sciencedirect.com/science/article/pii/S2212440323001463