Use of cytological smear and cell block technique for the diagnosis of plasma cell myeloma infiltration in the mandible

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dc.creatorFernanda Aragão Felix
dc.creatorAna Carolina Velasco Pondé de Sena
dc.creatorThalita Soares Tavares
dc.creatorDenise Vieira Travassos
dc.creatorFernanda Pereira Delgado Costa
dc.creatorRicardo Alves de Mesquita
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2024-11-06T22:43:12Z
dc.date.accessioned2025-09-09T01:13:27Z
dc.date.available2024-11-06T22:43:12Z
dc.date.issued2023-07
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2023.03.035
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/77854
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectDrug Therapy
dc.subjectCytology
dc.subjectDiagnosis
dc.subjectMultiple myeloma
dc.subjectHematopoietic stem cell transplantation
dc.subjectSyndecan-1
dc.subjectKi-67 antigen
dc.subjectImmunohistochemistry
dc.titleUse of cytological smear and cell block technique for the diagnosis of plasma cell myeloma infiltration in the mandible
dc.typeArtigo de periódico
local.citation.epagee24
local.citation.issue1
local.citation.spagee24
local.citation.volume136
local.description.resumoFine-needle aspiration cytology (FNAC) is a diagnostic tool using a needle to collect samples for cytopathological examina tion. We report a case of a 49-year-old male patient with previ ous medical history of plasma cell myeloma (PCM), who had osteolytic lesions in the mandible, diagnosed by FNAC. Imaging exams exhibited multiple osteolytic lesions with ill-defined mar gins in the bilateral mandibular body. FNAC of the intraosseous lesion of the mandible was performed. Cytological smear and cell block technique revealed plasma cells in different degrees of maturation, predominantly eccentric pleomorphic nuclei and abundant, eosinophilic cytoplasm without a paranuclear halo. Immunohistochemistry exhibited positivity for CD138, lambda light chain and Ki-67 (proliferation index was »50%). Based on clinicoradiographic, microscopic, and biochemical findings, the diagnosis was PCM infiltration in the mandible. The patient underwent chemotherapy and autologous hematopoietic stem cell transplantation, and had partial remission after 10 months of follow-up.
local.identifier.orcidhttps://orcid.org/0000-0003-3054-4642
local.identifier.orcidhttps://orcid.org/0000-0003-1083-9064
local.identifier.orcidhttps://orcid.org/0000-0001-7220-1360
local.identifier.orcidhttps://orcid.org/0000-0003-2084-9557
local.identifier.orcidhttps://orcid.org/0000-0002-0697-2463
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440323001463

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