Androgen receptor in salivary gland carcinoma: a review of an old marker as a possible new target
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
The role of the androgen receptor (AR) as an immunomarker for diagnosis of salivary gland duct carcinoma (SDC) is well known. Other non-squamous cell head and neck cancers (NSCC-HN), including a small subset of salivary gland cancers (SGCs), can also express AR. With the increase in effective and powerful new generation of anti-androgen agents and drugs administered orally, more targetable AR-driven NSCC-HN, such as subsets of SGCs, should be investigated for possible expression of AR. In this review, we focus on SGC subtypes, which could express AR and describe the main androgen deprivation therapy (ADT) strategies.
Abstract
Assunto
Abiraterone acetate, Receptors, androgen, Immunohistochemistry, Carcinoma, mucoepidermoid, Carcinoma, adenoid cystic, Adenocarcinoma, Prognosis, Radiotherapy, Excision repair, Androgen antagonists, Drug therapy
Palavras-chave
Abiraterone, androgen receptor, Enzalutamide, Head and neck, immunohistochemistry, Non-squamous cell carcinoma, Salivary gland carcinoma
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https://onlinelibrary.wiley.com/doi/10.1111/jop.12741