Molecular finds of pressure ulcer: a bioinformatics approach in pressure ulcer
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Background: understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. Objective: this study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. Methods: we performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions networks between protein-coding genes were built and compared to skin. Results: TNFA, MMP9, and IL10 genes have higher disease-related connectivity than a connectivity general global. MAGOH, UBC, and PTCH1 as were leader genes related to skin. Ontological analysis demonstrated different mechanisms associated, such as response to oxidase stress. Conclusion: TNFA, MMP9, and IL10 are possible therapeutic targets for pressure ulcer. Additional investigation of cell post-transcriptional machinery should be investigated in PU.
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Úlceras, Inflamação, Bioinformática
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https://www.sciencedirect.com/science/article/pii/S0965206X17300165