Molecular finds of pressure ulcer: a bioinformatics approach in pressure ulcer

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dc.creatorEloa Mangabeira Santos
dc.creatorLucyana Conceição Farias
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorCarla Silvana de Oliveira e Silva
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-24T16:44:11Z
dc.date.accessioned2025-09-09T00:55:53Z
dc.date.available2022-08-24T16:44:11Z
dc.date.issued2017-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.jtv.2017.01.002
dc.identifier.issn0965-206X
dc.identifier.urihttps://hdl.handle.net/1843/44541
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Tissue Viability
dc.rightsAcesso Aberto
dc.subjectÚlceras
dc.subjectInflamação
dc.subjectBioinformática
dc.titleMolecular finds of pressure ulcer: a bioinformatics approach in pressure ulcer
dc.typeArtigo de periódico
local.citation.epage124
local.citation.issue2
local.citation.spage119
local.citation.volume26
local.description.resumoBackground: understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. Objective: this study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. Methods: we performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions networks between protein-coding genes were built and compared to skin. Results: TNFA, MMP9, and IL10 genes have higher disease-related connectivity than a connectivity general global. MAGOH, UBC, and PTCH1 as were leader genes related to skin. Ontological analysis demonstrated different mechanisms associated, such as response to oxidase stress. Conclusion: TNFA, MMP9, and IL10 are possible therapeutic targets for pressure ulcer. Additional investigation of cell post-transcriptional machinery should be investigated in PU.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0965206X17300165

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